Karen M O'Shea Selected Research

Leptin

11/2009	A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload.
5/2008	Low-carbohydrate/high-fat diet attenuates pressure overload-induced ventricular remodeling and dysfunction.

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Karen M O'Shea Research Topics

Disease

12	Heart Failure 01/2013 - 11/2007
6	Hypertrophy 09/2010 - 01/2007
4	Cardiomegaly (Heart Hypertrophy) 10/2010 - 09/2008
3	Hypertension (High Blood Pressure) 06/2010 - 01/2007
3	Inflammation (Inflammations) 01/2010 - 02/2009
2	Reperfusion Injury 12/2017 - 12/2013
2	Myocardial Infarction 12/2013 - 12/2009
2	Cardiomyopathies (Cardiomyopathy) 05/2012 - 01/2012
2	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 11/2009 - 01/2007
2	Left Ventricular Dysfunction 12/2008 - 11/2007
2	Ventricular Remodeling 05/2008 - 11/2007
1	Myocardial Ischemia (Ischemic Heart Diseases) 12/2017
1	Body Weight (Weight, Body) 01/2017
1	Infarction (Infarctions) 12/2013
1	Acute Coronary Syndrome 12/2013
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 10/2013
1	Pre-Eclampsia (Preeclampsia) 10/2013
1	Rheumatoid Arthritis 10/2013
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2013
1	Hyperlipidemias (Hyperlipidemia) 10/2013
1	Obesity 09/2012
1	Diabetes Mellitus 09/2012
1	Heart Diseases (Heart Disease) 05/2012
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2012
1	Necrosis 02/2009
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2007

Drug/Important Bio-Agent (IBA)

5	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2013 - 11/2007
5	Fish OilsIBA 10/2010 - 02/2009
4	Docosahexaenoic AcidsIBA 01/2013 - 09/2009
4	Eicosapentaenoic AcidIBA 01/2013 - 09/2009
4	Insulin (Novolin)FDA Link 09/2012 - 01/2007
4	salicylhydroxamic acid (SHAM)IBA 09/2010 - 09/2008
3	AdiponectinIBA 06/2010 - 11/2007
2	LipidsIBA 01/2017 - 01/2007
2	Phosphotransferases (Kinase)IBA 09/2012 - 09/2008
2	Starch (Cornstarch)IBA 05/2012 - 12/2008
2	SugarsIBA 05/2012 - 12/2008
2	FructoseIBA 05/2012 - 12/2008
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 10/2010 - 12/2009
2	EnzymesIBA 06/2010 - 11/2009
2	LeptinIBA 11/2009 - 05/2008
2	CarbohydratesIBA 05/2008 - 01/2007
1	ForminsIBA 12/2017
1	CreatinineIBA 01/2017
1	MyostatinIBA 01/2017
1	PEGylated carboxyhemoglobin bovineIBA 12/2013
1	PEG-hemoglobinIBA 12/2013
1	Carbon MonoxideIBA 12/2013
1	Hemoglobins (Hemoglobin)IBA 12/2013
1	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2013
1	Acetaminophen (Paracetamol)FDA LinkGeneric 10/2013
1	LigandsIBA 10/2013
1	Glucose (Dextrose)FDA LinkGeneric 09/2012
1	Sucrose (Saccharose)IBA 05/2012
1	Sarcoglycans (beta Sarcoglycan)IBA 05/2012
1	Superoxides (Superoxide)IBA 05/2012
1	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2012
1	PalmitatesIBA 01/2012
1	Linolenic AcidsIBA 01/2012
1	StearatesIBA 01/2012
1	Mitochondrial Permeability Transition PoreIBA 10/2010
1	Messenger RNA (mRNA)IBA 06/2010
1	Hormones (Hormone)IBA 06/2010
1	Biological ProductsIBA 01/2010
1	Lipoproteins (Lipoprotein)IBA 01/2010
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 12/2009
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 11/2009
1	Phospholipids (Phosphatides)FDA LinkGeneric 09/2009
1	Cardiolipins (Cardiolipin)IBA 09/2009
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 09/2009
1	2,5-dichloro-4-bromophenol (B 2)IBA 02/2009
1	Linseed Oil (Flaxseed Oil)IBA 02/2009
1	ThromboxanesIBA 02/2009
1	tempolIBA 12/2008
1	AntioxidantsIBA 12/2008
1	Proto-Oncogene Proteins c-pim-1 (Proto Oncogene Proteins c pim 1)IBA 09/2008
1	p38 Mitogen-Activated Protein KinasesIBA 09/2008
1	AMP-Activated Protein KinasesIBA 09/2008
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2007
1	Dietary Fats (Dietary Fat)IBA 01/2007
1	AdipokinesIBA 01/2007
1	FatsIBA 01/2007

Therapy/Procedure

2	Fat-Restricted Diet (Diet, Fat Restricted) 01/2012 - 01/2007
1	Therapeutics 01/2010
1	Drug Therapy (Chemotherapy) 01/2010
1	Ligation 12/2009